Description

Dimethyl(tert-Butoxycarbonyl)-D-Glutamate is a high-purity, protected D-glutamate derivative, a crucial chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled, stereospecific incorporation of D-glutamic acid into complex peptide and peptidomimetic structures. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce D-glutamate residues with orthogonal protecting groups.
• Protease Inhibitor Development: Serves as a core component in the research and production of inhibitors targeting glutamate-specific proteases.
• Bioconjugation & Labeling: Facilitates the site-specific modification and labeling of peptides and proteins for diagnostic and research applications.
• Chemical Biology Research: Employed in the study of enzyme mechanisms, receptor-ligand interactions, and the structure-activity relationships (SAR) of peptides.
• Academic & R&D Laboratories: A standard reagent for synthetic organic chemistry research focused on amino acid chemistry and peptide mimetics.

Basic Information

Product Name	Dimethyl(tert-Butoxycarbonyl)-D-Glutamate
CAS No.	130622-05-8
Molecular Formula	C₁₂H₂₁NO₆
Molecular Weight	275.30 g/mol
Synonyms	Boc-D-Glu(OMe)-OMe; (2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]pentanedioic acid dimethyl ester; Dimethyl N-(tert-butoxycarbonyl)-D-glutamate; D-Glutamic acid, N-(1,1-dimethylethoxy)carbonyl-, dimethyl ester; Boc-D-Glu(OMe)-OCH₃; N-Boc-D-glutamic acid dimethyl ester; N-(tert-Butoxycarbonyl)-D-glutamic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our Dimethyl(tert-Butoxycarbonyl)-D-Glutamate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.