Description

(S,E)-Ethyl 3-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2-Methylacrylate is a high-value chiral building block and advanced pharmaceutical intermediate. This compound matters for its role in the stereoselective synthesis of complex molecules, offering precise control over molecular architecture critical for developing active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific stereochemistry and functional groups into their target compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of prostaglandins, antiviral agents, and other bioactive molecules requiring specific (S,E) stereochemistry.
• Agrochemical Synthesis: Used in the production of advanced chiral pesticides and herbicides where stereochemistry impacts biological activity.
• Fine Chemical Building Block: Employed in academic and industrial research for constructing complex natural products and novel chemical entities.
• Asymmetric Catalysis Research: Serves as a standard substrate or ligand precursor in the development of new asymmetric synthetic methodologies.
• Material Science Monomer: Potential use in creating specialized polymers with tailored properties from its acrylate functionality.

Basic Information

Product Name	(S,E)-Ethyl 3-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2-Methylacrylate
CAS No.	130606-67-6
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	(S,E)-Ethyl 3-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate; (4S)-4-[(1E)-2-Ethoxycarbonylprop-1-en-1-yl]-2,2-dimethyl-1,3-dioxolane; Ethyl (S,E)-3-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2-methylpropenoate; (S)-4-[(E)-2-(Ethoxycarbonyl)-1-propenyl]-2,2-dimethyl-1,3-dioxolane; Chiral Dioxolane Acrylate Ester; Acetal-protected Glyceraldehyde Acrylate Derivative
EINECS	Contact for details

Quality Control

Our (S,E)-Ethyl 3-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2-Methylacrylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and hydrolysis of the acetal protecting group. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.