Description

n-Desmethyldiltiazem, Hydrochloride is a key pharmaceutical intermediate and metabolite of the calcium channel blocker diltiazem. This compound is of significant value in pharmaceutical research and development, particularly for metabolic studies, pharmacokinetic profiling, and the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in cardiovascular drug development and bioanalytical method validation.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of diltiazem analogs and related cardiovascular drugs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical laboratories for the quantification of diltiazem and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic & Metabolic Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profile of diltiazem in preclinical and clinical research.
• Impurity Profiling: Serves as a known impurity or degradation product reference for quality control and stability testing of diltiazem active pharmaceutical ingredient (API) and finished dosage forms.
• Biochemical Research: Employed in studies exploring calcium channel modulation and related cellular signaling pathways.
• Method Development & Validation: Used to develop and validate chromatographic methods (HPLC, LC-MS) for pharmaceutical analysis.

Basic Information

Product Name	n-Desmethyldiltiazem, Hydrochloride
CAS No.	130606-60-9
Molecular Formula	C21H27ClN2O4S • HCl
Molecular Weight	479.43 g/mol
Synonyms	Desmethyldiltiazem Hydrochloride; N-Desmethyl Diltiazem HCl; N-Demethyldiltiazem Hydrochloride; Diltiazem N-Desmethyl Metabolite; (2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride; 1,5-Benzothiazepin-4(5H)-one, 5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-3-(acetyloxy)-, hydrochloride, (2S-cis)-; BRN 9070956; UNII-8V3Q6K2K4H
EINECS	Contact for details

Quality Control

Our n-Desmethyldiltiazem, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and impurity profiling, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.