Description

1-(2-Methoxyacetyl)Proline is a high-purity, specialized proline derivative characterized by its methoxyacetyl functional group. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where precise stereochemistry is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Employed as a building block in catalytic asymmetric reactions to create stereochemically defined molecules.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies and the development of protease inhibitors and other therapeutic agents.
• Chemical Biology: Acts as a probe or a component in the synthesis of labeled compounds for biochemical studies.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of specialty chemicals and advanced materials.

Basic Information

Product Name	1-(2-Methoxyacetyl)Proline
CAS No.	130603-11-1
Molecular Formula	C8H13NO4
Molecular Weight	187.19 g/mol
Synonyms	L-Proline, 1-(2-methoxyacetyl)-; (S)-1-(2-Methoxyacetyl)pyrrolidine-2-carboxylic acid; 2-Methoxy-N-[(2S)-pyrrolidin-2-ylcarbonyl]acetamide; 1-(Methoxyacetyl)-L-proline; Methoxyacetylproline; Proline Methoxyacetyl Derivative
EINECS	Contact for details

Quality Control

Our 1-(2-Methoxyacetyl)Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements of research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.