Description

Piperazine, 1-[2-(Trimethylsilyl)Ethyl]- (9Ci) is a specialized organosilicon derivative of piperazine, a versatile heterocyclic amine. This compound is valued for its role as a key synthetic intermediate and protecting group reagent in advanced organic synthesis. It is primarily required by research and development chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and cardiovascular systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the piperazine moiety for biological activity.
• Organosilicon Chemistry: Acts as a silylating agent or a precursor for introducing the trimethylsilylethyl (TMSE) protecting group for amines and other functional groups.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for metal-catalyzed reactions and organocatalysts due to its nitrogen donor atoms and silicon functionality.
• Polymer and Material Science: Utilized as a monomer or modifier in the synthesis of specialty polymers, silicones, and advanced materials with tailored properties.
• Research & Development: Essential for academic and industrial R&D in medicinal chemistry and process development for scale-up synthesis.

Basic Information

Product Name	Piperazine, 1-[2-(Trimethylsilyl)Ethyl]- (9Ci)
CAS No.	130596-57-5
Molecular Formula	C9H22N2Si
Molecular Weight	186.37 g/mol
Synonyms	1-(2-Trimethylsilylethyl)piperazine; N-(2-Trimethylsilylethyl)piperazine; 1-(2-(Trimethylsilyl)ethyl)piperazine; TMSE-Piperazine; (2-(Piperazin-1-yl)ethyl)trimethylsilane; Piperazine, 1-(2-(trimethylsilyl)ethyl)-; 130596-57-5
EINECS	Contact for details

Quality Control

Our Piperazine, 1-[2-(Trimethylsilyl)Ethyl]- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.