Description

Fmoc-L-Thr(β-D-Glc(Ac)4)-Oh is a sophisticated, orthogonally protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of glycosylated threonine residues, enabling the study of glycopeptide structure and function. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating complex therapeutic peptides and glycoconjugate vaccines.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of glycopeptides.
• Glycopeptide & Glycoprotein Research: Used to study the effects of O-linked glycosylation on peptide stability, bioavailability, and biological activity.
• Therapeutic Peptide Development: Enables the production of homogeneous glycopeptide candidates for oncology, metabolic disease, and antimicrobial applications.
• Vaccine Development: Serves as a building block for synthetic antigen constructs in conjugate vaccine research.
• Chemical Biology Probes: Facilitates the creation of labeled or tagged glycopeptides for mechanistic and binding studies.
• Process Development & Scale-Up: Supports the transition from research to GMP manufacturing of glycopeptide APIs.

Basic Information

Product Name	Fmoc-L-Thr(β-D-Glc(Ac)4)-Oh
CAS No.	130548-92-4
Molecular Formula	C₃₈H₄₃NO₁₅
Molecular Weight	753.75 g/mol
Synonyms	Fmoc-Thr[β-D-Glc(Ac)₄]-OH; N-α-Fmoc-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-L-threonine; Fmoc-L-threonine, O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-; Fmoc-Thr(Glc(Ac)4)-OH; Fmoc-T(β-D-Glc(Ac)₄)-OH; Glycosylated Fmoc-Threonine derivative; Fmoc protected glycosyl amino acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-Thr(β-D-Glc(Ac)4)-Oh is produced under strict quality management systems. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and MS to ensure high chemical purity and structural integrity, critical for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.