Description

8-((tert-Butoxycarbonyl)Amino)-5,6,7,8-Tetrahydronaphthalene-2-Carboxylic Acid CAS NO 130532-76-2 is a high-purity, protected amino acid derivative featuring a tetrahydronaphthalene (tetralin) scaffold, making it a critical building block in advanced organic synthesis. This compound is essential for research and development chemists requiring precise molecular architecture, particularly in the synthesis of complex pharmacologically active molecules. Its primary value lies in serving as a key intermediate for the construction of novel compounds targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those with tetralin-based structures for neurological and psychiatric applications.
• Peptidomimetics & Drug Discovery: Used to incorporate constrained, non-natural amino acid motifs into peptide analogs to enhance metabolic stability, bioavailability, and receptor selectivity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries in high-throughput screening (HTS) campaigns to identify new lead compounds.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme function and protein-protein interactions within biological systems.
• Agrochemical Synthesis: Potential intermediate in the development of novel agrochemicals with specific biological activity.
• Academic & Institutional R&D: Used in universities and research institutes for methodological development and the exploration of new synthetic pathways.

Basic Information

Product Name	8-((tert-Butoxycarbonyl)Amino)-5,6,7,8-Tetrahydronaphthalene-2-Carboxylic Acid
CAS No.	130532-76-2
Molecular Formula	C₁₇H₂₁NO₄
Molecular Weight	303.35 g/mol
Synonyms	Boc-8-Amino-5,6,7,8-tetrahydro-2-naphthoic Acid; 2-Naphthalenecarboxylic acid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-; 8-(Boc-amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid; 8-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; Boc-8-ATNA; 8-(N-Boc-amino)tetralin-2-carboxylic acid; (8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalen-2-yl)formic acid
EINECS	Contact for details

Quality Control

Our production of 8-((tert-Butoxycarbonyl)Amino)-5,6,7,8-Tetrahydronaphthalene-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.