Description

3,3-Difluoroglutamate is a high-value, fluorinated derivative of glutamic acid, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring two fluorine atoms at the 3-position, is engineered to modulate the metabolic stability, lipophilicity, and binding affinity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications in medicinal chemistry and proteomics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, including enzyme inhibitors and receptor modulators.
• Protease Inhibitor Synthesis: Used in constructing peptide mimetics and inhibitors targeting specific proteases for therapeutic applications.
• Agrochemical Research: Serves as a building block for developing new herbicides or pesticides with enhanced environmental stability and efficacy.
• Biochemical Tool Compound: Employed in biochemical assays and as a substrate analog to study enzyme mechanisms, particularly glutamate-related pathways.
• Peptide Chemistry: Incorporated into custom peptides to introduce fluorine atoms, altering their conformational stability and interaction with biological targets.
• Material Science Research: Potential precursor for specialty chemicals and advanced materials requiring fluorinated amino acid motifs.

Basic Information

Product Name	3,3-Difluoroglutamate
CAS No.	130521-05-0
Molecular Formula	C5H7F2NO4
Molecular Weight	183.11 g/mol
Synonyms	3,3-Difluoroglutamic Acid; DL-3,3-Difluoroglutamic Acid; (RS)-3,3-Difluoroglutamic Acid; 2-Amino-3,3-difluoropentanedioic Acid; 3,3-Difluoro-DL-glutamic Acid; Glutamic acid, 3,3-difluoro-; 130521-05-0; 3,3-Difluoro glutamate
EINECS	Contact for details

Quality Control

Our 3,3-Difluoroglutamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.