Description

1-(Ethoxycarbonyl)Piperidine-2-Carboxylic Acid is a versatile piperidine derivative and a key chiral building block in organic synthesis. Its bifunctional structure, featuring both a carboxylic acid and a protected amine, makes it an essential intermediate for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for creating peptide-like molecules with enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the synthesis of advanced herbicides and fungicides that require specific stereochemistry for optimal activity.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects in fine chemical and CDMO (Contract Development and Manufacturing Organization) facilities.
• Academic & Industrial R&D: Employed in research laboratories for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-(Ethoxycarbonyl)Piperidine-2-Carboxylic Acid
CAS No.	130497-14-2
Molecular Formula	C9H15NO4
Molecular Weight	201.22 g/mol
Synonyms	2-Piperidinecarboxylic acid, 1-(ethoxycarbonyl)-; Ethyl 1,2-piperidinedicarboxylate (ambiguous, often refers to diethyl ester); 1-Carbethoxy-2-piperidinecarboxylic Acid; 1-(Ethoxycarbonyl)piperidine-2-carboxylic acid; NSC 405124; 2-Carboxy-1-piperidinecarboxylic acid ethyl ester; Ethyl piperidine-1,2-dicarboxylate (acid form); (R/S)-1-(Ethoxycarbonyl)piperidine-2-carboxylic Acid (racemic mixture)
EINECS	Contact for details

Quality Control

Our 1-(Ethoxycarbonyl)Piperidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance in cGMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.