Description

tert-Butyl 3-(Methylsulfonyloxymethyl)-2,3-Dihydroindole-1-Carboxylate CAS NO 130469-60-2 is a high-purity, advanced pharmaceutical intermediate featuring a reactive mesylate leaving group. This compound is critical for the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutic agents, especially within the fields of oncology and neurology.

Application

• Key Intermediate in Drug Discovery: Serves as a versatile building block for the synthesis of indole-based drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its functionalized indole scaffold.
• Synthesis of Kinase Inhibitors: A crucial precursor in the development of targeted therapies, including various kinase inhibitors for cancer treatment.
• Peptidomimetic and Heterocyclic Chemistry: Employed in the construction of complex peptidomimetics and other nitrogen-containing heterocycles with potential biological activity.
• Process Chemistry & Scale-Up: Supplied for process research and development (PR&D) and pilot-scale manufacturing of clinical trial materials.
• Custom Synthesis Projects: Available for custom chemical synthesis and contract manufacturing organizations (CMOs) requiring specific, high-quality intermediates.

Basic Information

Product Name	tert-Butyl 3-(Methylsulfonyloxymethyl)-2,3-Dihydroindole-1-Carboxylate
CAS No.	130469-60-2
Molecular Formula	C16H23NO5S
Molecular Weight	341.42 g/mol
Synonyms	1-Boc-3-(methylsulfonyloxymethyl)indoline; 1-(tert-Butoxycarbonyl)-3-[(methylsulfonyl)oxy]methyl]indoline; tert-Butyl 3-((methylsulfonyloxy)methyl)indoline-1-carboxylate; 3-(Methylsulfonyloxymethyl)-2,3-dihydroindole-1-carboxylic acid tert-butyl ester; 1-Boc-3-(mesyloxymethyl)indoline; Indoline-1-carboxylic acid, 3-[(methylsulfonyl)oxy]methyl]-, 1,1-dimethylethyl ester; BOC-3-Mesyloxymethylindoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Methylsulfonyloxymethyl)-2,3-Dihydroindole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.