Description

Methanesulfonamide,n-[2-[(2R,12Bs)-1,3,4,6,7,12B-Hexahydro-2'-Oxospiro[2H-Benzofuro[2,3-A]Quinolizine-2,4'-Imidazolidin]-3'-Yl]Ethyl]-,Hydrochloride (1:1) is a high-purity, complex organic salt with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of novel therapeutic agents, particularly within central nervous system (CNS) and neurological research. This compound is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation drug candidates, where precise molecular structure and high purity are non-negotiable for successful clinical outcomes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of proprietary active pharmaceutical ingredients (APIs), especially for neurological targets.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) in preclinical research.
• Process Chemistry: Serves as a critical intermediate in scale-up and optimization studies for new drug manufacturing processes under GMP conditions.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Research: Potential use as a tool compound in pharmacological studies to investigate specific receptor interactions or enzymatic pathways.

Basic Information

Product Name	Methanesulfonamide,n-[2-[(2R,12Bs)-1,3,4,6,7,12B-Hexahydro-2'-Oxospiro[2H-Benzofuro[2,3-A]Quinolizine-2,4'-Imidazolidin]-3'-Yl]Ethyl]-,Hydrochloride (1:1)
CAS No.	130466-38-5
Molecular Formula	C₂₂H₃₀N₄O₄S·HCl
Molecular Weight	483.02 g/mol
Synonyms	N-[2-[(2R,12bS)-1,3,4,6,7,12b-Hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]methanesulfonamide hydrochloride; Spiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidine] methanesulfonamide derivative hydrochloride; (2R,12bS)-3'-[2-[(Methylsulfonyl)amino]ethyl]spiro[1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-2'-one hydrochloride
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality protocols are designed to meet the exacting standards required for GMP-grade intermediates and advanced synthetic chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Optical Rotation	Specific range available per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.