Description

2-Fluoro-n-n-Propylnorapomorphine is a fluorinated derivative of the aporphine class of alkaloids, representing a key intermediate in advanced pharmaceutical research and development. Its primary value lies in its utility for structure-activity relationship (SAR) studies and as a precursor for synthesizing novel dopaminergic receptor ligands. This compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on central nervous system (CNS) disorders, neurodegenerative diseases, and receptor pharmacology.

Application

• Pharmaceutical Research Intermediate: A critical building block for the synthesis of novel dopaminergic and serotonergic receptor-targeting compounds.
• Neuroscience & Neuropharmacology: Used in preclinical studies to investigate receptor binding affinity, selectivity, and functional activity.
• Medicinal Chemistry: Serves as a core scaffold for the design and optimization of new chemical entities (NCEs) for CNS applications.
• Biochemical Assay Development: Employed as a reference standard or ligand in high-throughput screening (HTS) and in vitro assay systems.
• Academic Research: Utilized in university and institutional labs for fundamental research on aporphine alkaloids and their biological effects.
• Process Chemistry & Scale-Up: Acts as a key intermediate in the development and optimization of synthetic routes for potential active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Fluoro-n-n-Propylnorapomorphine
CAS No.	130434-40-1
Molecular Formula	C19H22FNO2
Molecular Weight	315.39 g/mol
Synonyms	2-Fluoro-N-n-propylnorapomorphine; 2-Fluoro-11-hydroxy-N-n-propylnoraporphine; 2-Fluoro-10,11-dihydroxy-N-propylnoraporphine; 2-Fluoro-N-propylnorapomorphine; 2-F-NPA; 2-Fluoroaporphine derivative; (R)-2-Fluoro-11-hydroxy-N-propylnoraporphine; 2-Fluoro-10,11-dihydroxyaporphine-N-propyl
EINECS	Contact for details

Quality Control

Our 2-Fluoro-n-n-Propylnorapomorphine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light tan powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.