Description

1-Pyrrolidinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester, (2R)- is a high-value, chiral building block featuring a pyrrolidine core with an ethynyl substituent, protected as a tert-butyl ester. This compound matters as a critical intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting neurological and metabolic disorders, due to its rigid, functionalized structure that enables precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) targets.
• Peptidomimetic Synthesis: Used to incorporate constrained, proline-like structures into peptide analogs to enhance stability and biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing specialized ligands used in asymmetric hydrogenation and other chiral transformations.
• Chemical Biology Probes: Utilized in the creation of molecular probes featuring an alkyne handle for "click chemistry" conjugation to study biological systems.
• Agrochemical Research: Employed in the discovery of novel, enantiomerically pure crop protection agents.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester, (2R)-
CAS No.	130418-90-5
Molecular Formula	C11H17NO2
Molecular Weight	195.26 g/mol
Synonyms	(R)-2-Ethynyl-1-(tert-butoxycarbonyl)pyrrolidine; (R)-N-Boc-2-ethynylpyrrolidine; tert-Butyl (2R)-2-ethynyl-1-pyrrolidinecarboxylate; (R)-1-Boc-2-ethynylpyrrolidine; (R)-2-Ethynylpyrrolidine-1-carboxylic acid tert-butyl ester; (2R)-2-Ethynyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine; BOC-(R)-2-ethynylpyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester, (2R)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric purity, to meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.