Description

(S)-3-((tert-Butyldimethylsilyl)Oxy)Pyrrolidin-2-One is a high-purity, chiral building block featuring a protected hydroxyl group on a pyrrolidinone scaffold. This compound is critically important for the synthesis of complex pharmaceutical intermediates, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for asymmetric synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of various drug candidates, particularly those targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Used as a building block for constructing complex molecules with defined stereochemistry in medicinal chemistry.
• API Development: Serves as a precursor in the research and scale-up production of new Active Pharmaceutical Ingredients (APIs).
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals requiring specific stereochemical configurations.
• Agrochemical Research: Utilized in the development of novel, chiral pesticides and herbicides.
• Academic & Contract Research: A valuable reagent for academic research and contract research organizations (CROs) focused on organic methodology and total synthesis.

Basic Information

Product Name	(S)-3-((tert-Butyldimethylsilyl)Oxy)Pyrrolidin-2-One
CAS No.	130403-91-7
Molecular Formula	C10H21NO2Si
Molecular Weight	215.37 g/mol
Synonyms	(S)-3-[(tert-Butyldimethylsilyl)oxy]-2-pyrrolidinone; (S)-3-(tert-Butyldimethylsiloxy)pyrrolidin-2-one; (S)-N-Boc-3-(tert-butyldimethylsilyloxy)pyrrolidine-2-one (related protected form); (S)-3-TBDMS-Oxy-2-pyrrolidinone; 2-Pyrrolidinone, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3S)-; TBDMS-protected (S)-3-hydroxypyrrolidin-2-one; (S)-3-Hydroxy-2-pyrrolidinone TBDMS ether
EINECS	Contact for details

Quality Control

Our (S)-3-((tert-Butyldimethylsilyl)Oxy)Pyrrolidin-2-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.