Description

6-n-Benzoyl-5'-o-Benzyl-2'-Deoxyadenosine is a key protected nucleoside derivative, specifically a benzoylated and benzylated analog of 2'-deoxyadenosine. This compound is critically important as a high-purity building block in the synthesis of oligonucleotides and modified nucleic acids. It is primarily required by research institutions and pharmaceutical companies engaged in antisense drug development, diagnostic probe synthesis, and advanced nucleotide chemistry.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a protected phosphoramidite precursor for automated DNA synthesis.
• Antisense and siRNA Therapeutic Research: Used in the preparation of modified oligonucleotides for gene silencing applications.
• Diagnostic Probe Manufacturing: A key raw material for producing labeled DNA probes used in molecular diagnostics (e.g., PCR, FISH).
• Nucleotide Chemistry & Medicinal Chemistry: Employed in the research and development of novel nucleoside-based pharmaceuticals.
• Academic & Industrial R&D: Utilized in laboratories for studying nucleic acid structure, function, and for creating custom oligonucleotide libraries.

Basic Information

Product Name	6-n-Benzoyl-5'-o-Benzyl-2'-Deoxyadenosine
CAS No.	130359-85-2
Molecular Formula	C24H23N5O4
Molecular Weight	445.47 g/mol
Synonyms	N6-Benzoyl-5'-O-benzyl-2'-deoxyadenosine; 5'-O-Benzyl-N6-benzoyl-2'-deoxyadenosine; 2'-Deoxy-N6-benzoyl-5'-O-benzyladenosine; 2'-Deoxyadenosine, N6-benzoyl-5'-O-benzyl-; Bn-dABz; 5'-O-Benzyl-2'-deoxy-N6-benzoyladenosine
EINECS	Contact for details

Quality Control

Our 6-n-Benzoyl-5'-o-Benzyl-2'-Deoxyadenosine is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive oligonucleotide synthesis. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to meet the demands of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.