Description

cis-2-Chloro-2-Fluorocyclopropanamine Hydrochloride is a high-purity, functionalized cyclopropane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique halogenated cyclopropane structure makes it a valuable intermediate for constructing complex molecules with specific three-dimensional geometries. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-infective therapies.
• Agrochemical Synthesis: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the fluorinated cyclopropane moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes to study enzyme mechanisms and biological pathways.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing polymers with unique thermal or mechanical properties.

Basic Information

Product Name	cis-2-Chloro-2-Fluorocyclopropanamine Hydrochloride
CAS No.	130340-17-9
Molecular Formula	C3H6Cl2FN
Molecular Weight	158.00 g/mol
Synonyms	1-Amino-2-chloro-2-fluorocyclopropane hydrochloride; (1R,2S)-rel-2-Chloro-2-fluorocyclopropanamine hydrochloride; 2-Chloro-2-fluorocyclopropan-1-amine hydrochloride; cis-2-Chloro-2-fluorocyclopropan-1-amine hydrochloride; 2-Fluoro-2-chlorocyclopropanamine HCl; Aminofluorochlorocyclopropane hydrochloride; Cyclopropanamine, 2-chloro-2-fluoro-, hydrochloride, cis-
EINECS	Contact for details

Quality Control

Our cis-2-Chloro-2-Fluorocyclopropanamine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation upon exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.