Description

trans-2-Chloro-2-Fluorocyclopropaneamine Hydrochloride is a high-purity, functionalized cyclopropane building block of significant interest in advanced organic synthesis. Its unique halogenated cyclopropane structure makes it a valuable precursor for the development of novel pharmaceutical intermediates and agrochemicals. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate stereodefined, strained-ring motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of bioactive molecules, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and insecticides that leverage the metabolic stability of the cyclopropane ring.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and organometallic complexes.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study biological pathways and protein function.
• Material Science Precursor: Can be utilized in the synthesis of monomers or additives for specialized polymers with unique properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	trans-2-Chloro-2-Fluorocyclopropaneamine Hydrochloride
CAS No.	130340-10-2
Molecular Formula	C3H6Cl2FN
Molecular Weight	158.00 g/mol
Synonyms	trans-1-Amino-2-chloro-2-fluorocyclopropane hydrochloride; (1R,2S)-2-Chloro-2-fluorocyclopropanamine hydrochloride (and enantiomer); 2-Chloro-2-fluorocyclopropanamine HCl; 2-Fluoro-2-chlorocyclopropanamine hydrochloride; trans-2-Fluoro-2-chlorocyclopropan-1-amine hydrochloride; 130340-10-2; 2-Chloro-2-fluorocyclopropylamine hydrochloride
EINECS	Contact for details

Quality Control

Our trans-2-Chloro-2-Fluorocyclopropaneamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.