Description

T-Butyl 4-Boc-(S)-Amino-5-Hydroxypentanoate is a high-purity, chiral building block of significant importance in advanced organic synthesis. This compound serves as a critical intermediate for the construction of complex molecules, particularly in the pharmaceutical sector where stereochemical control is paramount. It is primarily needed by research institutions and manufacturers engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce protected amino acid derivatives with specific stereochemistry.
• Prodrug Development: Serves as a precursor for prodrug strategies, where the tert-butyl and Boc groups facilitate controlled release of the active moiety.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes, enzyme substrates, and inhibitors for biochemical studies.
• Custom Synthesis: A versatile starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	T-Butyl 4-Boc-(S)-Amino-5-Hydroxypentanoate
CAS No.	130333-58-3
Molecular Formula	C14H27NO5
Molecular Weight	289.37 g/mol
Synonyms	(S)-5-Hydroxy-4-[(tert-butoxycarbonyl)amino]pentanoic acid tert-butyl ester; tert-Butyl (4S)-4-[(tert-butoxycarbonyl)amino]-5-hydroxypentanoate; Boc-L-Homoserine(tBu)-OH; Boc-Hse(tBu)-OH; (S)-4-(Boc-amino)-5-hydroxy-pentanoic acid tert-butyl ester; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxy-(S)-pentanoic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our T-Butyl 4-Boc-(S)-Amino-5-Hydroxypentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.