Description

L-Homophenylalanine tert-Butyl Ester Hydrochloride is a high-purity, non-natural amino acid derivative widely used as a critical chiral building block in organic synthesis. Its value lies in providing a protected, enantiomerically pure phenylalanine analog essential for constructing complex peptide-based pharmaceuticals and bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other peptidomimetic drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for cardiovascular and antiviral drugs.
• Peptidomimetics Research: Serves as a crucial building block for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Used in the construction of inhibitors targeting specific enzymes like renin, HIV protease, and thrombin.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective chemical reactions to introduce chiral centers.
• Bioconjugation & Labeling: The reactive ester group and protected amine facilitate its use in creating labeled peptides or protein conjugates for diagnostic applications.
• Academic & Industrial R&D: Essential for medicinal chemistry programs exploring new chemical entities and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	L-Homophenylalanine tert-Butyl Ester Hydrochloride
CAS No.	130316-46-0
Molecular Formula	C14H21NO2 • HCl
Molecular Weight	271.78 g/mol (Free base: 235.32 g/mol)
Synonyms	(S)-2-Amino-4-phenylbutanoic acid 1,1-dimethylethyl ester hydrochloride; L-2-Amino-4-phenylbutyric acid tert-butyl ester HCl; Hphg-OtBu•HCl; tert-Butyl L-homophenylalaninate hydrochloride; (S)-tert-Butyl 2-amino-4-phenylbutanoate hydrochloride; Homophenylalanine tert-butyl ester HCl; Boc-Hphg-OtBu precursor (related); L-α-Amino-γ-phenylbutyric acid tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our L-Homophenylalanine tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.