Description

Fmoc-Oic-Oh CAS NO 130309-37-4 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient construction of complex peptide sequences. It is primarily required by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential addition of amino acids using Fmoc-chemistry protocols.
• Peptidomimetic Drug Discovery: Used in the research and development of novel drug candidates that mimic natural peptides.
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides for diagnostic or targeting applications.
• Combinatorial Chemistry Libraries: Serves as a building block for generating diverse arrays of peptide-based compounds for high-throughput screening.
• Academic and Industrial Research: Employed in biochemical studies to investigate protein-protein interactions and enzyme mechanisms.
• Custom Peptide Manufacturing: A fundamental raw material for contract research organizations (CROs) and CDMOs producing peptides at various scales.

Basic Information

Product Name	Fmoc-Oic-Oh
CAS No.	130309-37-4
Molecular Formula	C₂₀H₁₉NO₅
Molecular Weight	353.37 g/mol
Synonyms	Fmoc-Oic-OH; (3S,4aS,8aS)-3-[(9H-Fluoren-9-ylmethoxy)carbonyl]octahydroindole-2-carboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-octahydroindole-2-carboxylic Acid; Fmoc-Octahydroindole-2-carboxylic Acid; Fmoc-Oic; N-Fmoc-cis-Octahydroindole-2-carboxylic Acid; Fmoc-D-Oic-OH (for D-isomer reference); Fmoc-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-Oic-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical applications, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.