Description

n-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is a critical chiral building block, valued for its role in constructing complex peptide architectures with precise stereochemical control. It is primarily utilized by pharmaceutical R&D teams, CROs, and CDMOs engaged in the development of peptide-based therapeutics, diagnostics, and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential assembly of peptides, particularly those containing the constrained tetrahydroisoquinoline scaffold.
• Pharmaceutical Research: Used in the discovery and development of novel peptide drugs targeting GPCRs, enzymes, and other biological pathways.
• Peptidomimetic Design: Serves as a core structure for creating stable, bioactive peptidomimetics with enhanced metabolic stability and receptor affinity.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new lead compounds with therapeutic potential.
• Bioconjugation: Can be used to introduce the tetrahydroisoquinoline carboxylic acid moiety into proteins, antibodies, or other biomolecules.
• Academic Research: A valuable reagent for studies in organic chemistry, medicinal chemistry, and chemical biology focusing on peptide structure-activity relationships.

Basic Information

Item	Detail
Product Name	n-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	130309-33-0
Molecular Formula	C26H23NO4
Molecular Weight	413.47 g/mol
Synonyms	Fmoc-D-Tic-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid N-9-fluorenylmethyloxycarbonyl derivative; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic Acid; Fmoc-D-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; N-Fmoc-D-tetrahydroisoquinoline-3-carboxylic acid; Fmoc-3-(2-carboxyethyl)-D-phenylalanine (cyclic analog)
EINECS	Contact for details

Quality Control

Every batch of n-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured and tested under a strict quality management system. We ensure compliance with the high-purity standards required for pharmaceutical research and peptide synthesis. Comprehensive analytical testing, including HPLC, NMR, and optical rotation, is performed. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.