Description

(E)-2'-Deoxy-2'-(Fluoromethylene) Cytidine is a fluorinated nucleoside analog, a key intermediate in the development of novel antiviral and anticancer therapeutics. Its unique structure, featuring a fluoromethylene group, is critical for imparting metabolic stability and enhancing biological activity in drug candidates. This high-purity compound is essential for pharmaceutical R&D, specifically for medicinal chemists and researchers developing nucleoside-based prodrugs and targeted therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced nucleoside antiviral and anticancer agents.
• Antiviral Drug Research: Used in the development of novel therapeutics targeting viral polymerases for diseases such as hepatitis and herpes.
• Oncology Research: Serves as a precursor for cytostatic compounds that inhibit cancer cell proliferation by interfering with DNA synthesis.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism pathways.
• Prodrug Development: Employed in creating masked nucleoside analogs designed for improved bioavailability and targeted delivery.

Basic Information

Product Name	(E)-2'-Deoxy-2'-(Fluoromethylene) Cytidine
CAS No.	130306-02-4
Molecular Formula	C10H13FN4O4
Molecular Weight	272.24 g/mol
Synonyms	2'-Deoxy-2'-(fluoromethylene)cytidine; (E)-2'-Deoxy-2'-(fluoromethylene)cytidine; FMdC; Fluoromethylene dCytidine; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)-3,4-dihydrofuran-2-yl)-4-amino-2(1H)-pyrimidinone; 4-Amino-1-((2R,4S,5R)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 2'-Fluoromethylene-2'-deoxycytidine
EINECS	Contact for details

Quality Control

Our (E)-2'-Deoxy-2'-(Fluoromethylene) Cytidine is manufactured under strict quality systems suitable for research and development use. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide comprehensive Certificates of Analysis (COA) detailing all specifications to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.