Description

Methyl (1R,3R,4S)-2-((1S)-1-Phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate is a high-purity chiral bicyclic lactam derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in its defined stereochemistry, which is essential for synthesizing enantiomerically pure compounds with targeted biological activity. This product is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) with specific stereochemical requirements.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.
• Medicinal Chemistry Research: Employed in drug discovery programs for constructing constrained, bicyclic frameworks to explore structure-activity relationships (SAR).
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes to complex drug candidates under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	Methyl (1R,3R,4S)-2-((1S)-1-Phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate
CAS No.	130195-74-3
Molecular Formula	C16H19NO2
Molecular Weight	257.33 g/mol
Synonyms	(1R,3R,4S)-Methyl 2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate; (1S,2R,4R)-Methyl 2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate; (1R,3R,4S)-3-(Methoxycarbonyl)-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene; 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid, 2-[(1S)-1-phenylethyl]-, methyl ester, (1R,3R,4S)-; Methyl endo-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate; Chiral bicyclic lactam ester.
EINECS	Contact for details

Quality Control

Our Methyl (1R,3R,4S)-2-((1S)-1-Phenylethyl)-2-Azabicyclo[2.2.1]Hept-5-Ene-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.