Description

Methyl (1S,3S,4R)-2-((1R)-1-Phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate is a high-purity, chiral bicyclic lactam derivative that serves as a critical advanced intermediate in organic synthesis. Its value lies in its rigid, three-dimensional scaffold and defined stereochemistry, which is essential for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), particularly in the areas of neurology and antiviral therapies.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially those targeting the central nervous system.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Development: Serves as a starting material or intermediate in the scale-up and optimization of API manufacturing routes.
• Academic & Contract Research: Used in university and CRO laboratories for methodological development in synthetic organic chemistry.
• Fine Chemical Production: Incorporated into the synthesis of specialty chemicals requiring a specific, constrained bicyclic framework.

Basic Information

Product Name	Methyl (1S,3S,4R)-2-((1R)-1-Phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate
CAS No.	130194-96-6
Molecular Formula	C16H19NO2
Molecular Weight	257.33 g/mol
Synonyms	(1S,3S,4R)-Methyl 2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate; (1R,2S,4S)-Methyl 2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate; 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid, 2-[(1R)-1-phenylethyl]-, methyl ester, (1S,3S,4R)-; Methyl endo-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate; Chiral bicyclic lactam ester; (1S,3S,4R,1'R)-Methyl 2-(1'-phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality control protocols, ensuring batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, and chiral analysis. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.