Description

(R)-Norfluoxetine CAS NO 130194-43-3 is the (R)-enantiomer of the major active metabolite of the widely prescribed antidepressant fluoxetine. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereoselective drug metabolism and the synthesis of novel therapeutic agents. It is essential for scientists and manufacturers in the pharmaceutical and fine chemical industries focused on developing enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of enantiomerically pure antidepressants and related central nervous system (CNS) active compounds.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical laboratories for pharmacokinetic and pharmacodynamic studies of fluoxetine.
• Stereochemistry Research: Serves as a pure enantiomeric standard in academic and industrial research investigating the distinct biological activities of individual fluoxetine enantiomers and metabolites.
• Process Development: Employed in the development and validation of asymmetric synthesis routes and chiral separation methods within fine chemical manufacturing.
• Impurity Profiling: Utilized as an analytical standard to identify and quantify stereoisomeric impurities in fluoxetine API batches, ensuring product quality and regulatory compliance.

Basic Information

Product Name	(R)-Norfluoxetine
CAS No.	130194-43-3
Molecular Formula	C16H16F3NO
Molecular Weight	295.30 g/mol
Synonyms	(R)-Norfluoxetine; (R)-N-Desmethylfluoxetine; (R)-3-Phenyl-3-[(αR)-α-methyl-4-(trifluoromethyl)phenoxy]propylamine; (R)-3-(4-Trifluoromethylphenoxy)-3-phenylpropylamine; (R)-LY-248686; (R)-Fluoxetine Metabolite; (R)-Desmethylfluoxetine; (R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine (de-methylated form)
EINECS	Contact for details

Quality Control

Our (R)-Norfluoxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.