Description

4-Bromo-3,5-difluorophenol is a halogenated phenolic compound that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing monomers and polymers used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce halogenated phenolic groups into specialty polymers, improving flame retardancy and thermal stability.
• Organic Synthesis Building Block: Employed in Suzuki, Buchwald-Hartwig, and other cross-coupling reactions to introduce the difluorophenol moiety into more complex aromatic systems.
• Material Science Research: Utilized in academic and industrial R&D for developing novel fluorinated materials with specific optical or electronic properties.

Basic Information

Product Name	4-Bromo-3,5-difluorophenol
CAS No.	130191-91-2
Molecular Formula	C6H3BrF2O
Molecular Weight	208.99 g/mol
Synonyms	3,5-Difluoro-4-bromophenol; 4-Bromo-3,5-difluorophenol; Phenol, 4-bromo-3,5-difluoro-; 4-Bromo-3,5-difluoro-1-hydroxybenzene; 1-Bromo-2,6-difluoro-4-hydroxybenzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-3,5-difluorophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its phenolic and fluoride nature, ensure proper handling procedures are followed.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	68 - 72 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.