Description

5'-o-(4,4'-Dimethoxytrityl)-N2-Phenoxyacetyl-2'-Deoxyguanosine-3'-o-Succinate is a high-purity, protected nucleoside phosphoramidite precursor, a critical building block in automated oligonucleotide synthesis. This compound matters for its role in ensuring high coupling efficiency and sequence fidelity during the solid-phase synthesis of DNA and RNA strands. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable, high-quality raw materials for producing primers, probes, and therapeutic oligonucleotides.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated solid-phase synthesis of DNA sequences.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense oligonucleotides, siRNA, and aptamers for drug development.
• Diagnostic Probe Production: Synthesis of labeled probes for PCR, qPCR, FISH, and microarray technologies.
• Research & Development: Used in academic and industrial labs for custom gene synthesis and molecular biology research.
• Next-Generation Sequencing (NGS): Manufacture of primers and adapters used in sequencing platforms.
• CRISPR-Cas9 System Components: Synthesis of guide RNAs (gRNAs) and other synthetic nucleic acid tools.

Basic Information

Product Name	5'-o-(4,4'-Dimethoxytrityl)-N2-Phenoxyacetyl-2'-Deoxyguanosine-3'-o-Succinate
CAS No.	130150-80-0
Molecular Formula	C45H45N5O11
Molecular Weight	831.87 g/mol
Synonyms	dG(Pac)-DMTr-succinate; N-Pac-5'-O-DMTr-2'-deoxyguanosine-3'-succinate; 2'-Deoxyguanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[2-(phenoxyacetyl)]-, 3'-hydrogen succinate; Guanosine, 2'-deoxy-, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[2-(phenoxyacetyl)]-, 3'-(hydrogen succinate); PAC-dG(DMTr)-Succinate; Protected Deoxyguanosine Phosphoramidite Precursor; N2-Phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-O-succinate
EINECS	Contact for details

Quality Control

Our 5'-o-(4,4'-Dimethoxytrityl)-N2-Phenoxyacetyl-2'-Deoxyguanosine-3'-o-Succinate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical and diagnostic manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under anhydrous conditions. This material is hygroscopic (moisture-sensitive) and should be handled in a dry, inert atmosphere to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.