Description

n-Me-D-Leu-Ome·Hcl CAS NO 130115-50-3 is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of N-methyl-D-leucine. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including peptide-based drugs and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediates: A key chiral synthon in the multi-step synthesis of peptide-based Active Pharmaceutical Ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the N-methyl-D-leucine residue, which can enhance metabolic stability and alter conformational properties.
• Research & Development: Serves as a critical reagent in medicinal chemistry for the design and optimization of novel peptidomimetics and protease inhibitors.
• Bioconjugation: Can be employed in the preparation of peptide conjugates for targeted drug delivery systems and diagnostic probes.
• Chemical Biology: Useful in the synthesis of labeled peptides and molecular probes for studying biological pathways and protein-protein interactions.

Basic Information

Product Name	n-Me-D-Leu-Ome·Hcl
CAS No.	130115-50-3
Molecular Formula	C8H18ClNO2
Molecular Weight	195.69 g/mol
Synonyms	N-Methyl-D-leucine methyl ester hydrochloride; Methyl (2R)-2-[(methylamino)methyl]-4-methylpentanoate hydrochloride; D-N-Methylleucine methyl ester HCl; (R)-2-(Methylaminomethyl)-4-methylpentanoic acid methyl ester hydrochloride; H-D-N-Me-Leu-OMe·HCl; Fmoc-N-Me-D-Leu-OH methyl ester hydrochloride (precursor form); Boc-N-Me-D-Leu-OMe·HCl (precursor form)
EINECS	Contact for details

Quality Control

Our n-Me-D-Leu-Ome·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.