Description

Carbomethoxycarbonyl-Pro-Phe-Obzl is a protected tripeptide derivative, specifically a benzyl ester of a proline-phenylalanine dipeptide with a carbomethoxycarbonyl (Cbz) protecting group on the N-terminus. This compound is a crucial building block (intermediate) in the multi-step synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the solid-phase and solution-phase synthesis of target peptide sequences for drug discovery and development.
• Protease Inhibitor Research: Serves as a core scaffold or intermediate in the design and synthesis of inhibitors targeting enzymes like prolyl oligopeptidase or dipeptidyl peptidase IV.
• Bioconjugation & Labeling: The reactive ester group and protected amines make it suitable for creating peptide conjugates for diagnostic or research purposes.
• Academic & Institutional Research: Used in university and institutional labs for studying peptide chemistry, enzyme-substrate interactions, and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Employed in custom synthesis projects for producing non-standard amino acid derivatives and specialized chiral compounds.

Basic Information

Product Name	Carbomethoxycarbonyl-Pro-Phe-Obzl
CAS No.	129987-97-9
Molecular Formula	C24H26N2O6
Molecular Weight	438.48 g/mol
Synonyms	Z-Pro-Phe-OBzl; Cbz-Pro-Phe-OBzl; Benzyl N-[(benzyloxy)carbonyl]-L-prolyl-L-phenylalaninate; N-Carbobenzoxy-L-prolyl-L-phenylalanine benzyl ester; Z-L-Prolyl-L-phenylalanine benzyl ester; (S)-Benzyl 1-((S)-2-((benzyloxy)carbonylamino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxylate; CBZ-Pro-Phe-OBzl; Z-Pro-Phe-OBzl
EINECS	Contact for details

Quality Control

Our Carbomethoxycarbonyl-Pro-Phe-Obzl is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and residual solvents are available upon request. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-L isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.