Description

9-((2-(Hydroxymethyl)Cyclohexyl)Methyl)Guanine is a high-purity, synthetic nucleoside analog with a modified cyclohexylmethyl side chain. This structural modification makes it a valuable intermediate in advanced pharmaceutical research and development, particularly for antiviral and anticancer therapeutic agents. It is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of novel nucleotide-based drugs, prodrug development, and biochemical studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA/RNA synthesis and repair.
• Prodrug Development: Serves as a core structure for designing prodrugs with enhanced bioavailability and targeted delivery.
• Antiviral Agent Research: Investigated for activity against herpesviruses and other DNA viruses due to its guanine base structure.
• Labeled Compound Synthesis: Precursor for creating radiolabeled or fluorescently tagged compounds for diagnostic and tracking applications.
• Academic & Contract Research: Utilized in university and CRO laboratories for medicinal chemistry and drug discovery programs.

Basic Information

Product Name	9-((2-(Hydroxymethyl)Cyclohexyl)Methyl)Guanine
CAS No.	129982-32-7
Molecular Formula	C14H21N5O2
Molecular Weight	291.35 g/mol
Synonyms	9-[(2-(Hydroxymethyl)cyclohexyl)methyl]guanine; 9-((2-Hydroxymethyl-cyclohexyl)methyl)-guanine; Guanine, 9-[(2-(hydroxymethyl)cyclohexyl)methyl]-; 2-Amino-9-((2-(hydroxymethyl)cyclohexyl)methyl)-1,9-dihydro-6H-purin-6-one; Cyclohexanemethanol, α-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methyl-; HMC-Guanine
EINECS	Contact for details

Quality Control

Our 9-((2-(Hydroxymethyl)Cyclohexyl)Methyl)Guanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.