Description

Ethanone, 1-[(1R,3S)-3-(Hydroxymethyl)-2,2-Dimethylcyclobutyl]-, Rel- (9Ci) CAS NO 129940-75-6 is a high-purity, stereochemically defined cyclobutane derivative featuring both a ketone and a hydroxymethyl functional group. This unique chiral structure makes it a valuable advanced pharmaceutical intermediate (API) and a versatile building block for asymmetric synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly in antiviral, anti-inflammatory, or central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used as a building block in the research and production of novel, stereospecific pesticides and herbicides.
• Fine Chemical Production: Serves as a precursor for fragrances, flavors, and other specialty chemicals requiring specific stereochemistry.
• Asymmetric Catalysis Research: Employed as a standard or substrate in academic and industrial research to develop new chiral catalysts and synthetic methodologies.
• Material Science: Potential monomer or cross-linking agent for creating polymers with tailored optical or mechanical properties.

Basic Information

Product Name	Ethanone, 1-[(1R,3S)-3-(Hydroxymethyl)-2,2-Dimethylcyclobutyl]-, Rel- (9Ci)
CAS No.	129940-75-6
Molecular Formula	C9H16O2
Molecular Weight	156.22 g/mol
Synonyms	rel-(1R,3S)-3-(Hydroxymethyl)-2,2-dimethylcyclobutyl methyl ketone; (1R,3S)-3-(Hydroxymethyl)-2,2-dimethylcyclobutan-1-yl methyl ketone; 2,2-Dimethyl-3-(hydroxymethyl)cyclobutyl methyl ketone (rel); Cyclobutane derivative, 129940-75-6; Chiral cyclobutane ketone; (rel)-1-[(1R,3S)-3-(Hydroxymethyl)-2,2-dimethylcyclobutyl]ethanone
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, chiral analysis, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, enantiomeric excess, and impurity profiles to meet your specific R&D or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.