Description

6-Nor-6-Cyanodihydroergotamine is a key synthetic intermediate and reference standard in advanced pharmaceutical research and development. This compound is of significant value for its role in the synthesis and analytical characterization of complex ergot alkaloid derivatives. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the synthetic pathway for novel ergot-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) testing in pharmaceutical analysis via HPLC, LC-MS, or GC-MS.
• Biochemical Research: Serves as a tool compound for studying serotonin (5-HT) receptor interactions and related pharmacological mechanisms.
• Process Chemistry & Scale-up: Employed in route scouting and optimization studies for the commercial manufacturing of specialized pharmaceuticals.
• Metabolite Studies: Used as a standard in the identification and quantification of drug metabolites during preclinical and clinical research.

Basic Information

Product Name	6-Nor-6-Cyanodihydroergotamine
CAS No.	129882-18-4
Molecular Formula	C34H37N5O5
Molecular Weight	595.69 g/mol
Synonyms	6-Nor-6-cyano-9,10-dihydroergotamine; 6-Cyano-6-nordihydroergotamine; Dihydroergotamine-6-carbonitrile; 6-Nor-6-CN-DHE; (5'α)-9,10-Didehydro-12'-hydroxy-2'-methyl-6'-(2-methylpropyl)ergotaman-3',6',18-trione 6-carbonitrile; 6-Cyanonordihydroergotamine; 6-Nor-6-cyano-DHE
EINECS	Contact for details

Quality Control

Our 6-Nor-6-Cyanodihydroergotamine is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.