Description

1,1,1-Trifluoro-Methanesulfonic Acid 2-Acetylphenyl Ester is a specialized fluorinated sulfonate ester building block of significant interest in advanced organic synthesis. Its core value lies in its ability to act as a potent and selective trifluoromethanesulfonylating or arylating agent, enabling the introduction of valuable functional groups into complex molecular architectures. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those requiring trifluoromethylsulfonyl (SO2CF3) or specific aryl motifs.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Organic Synthesis Reagent: Employed as a robust electrophile in cross-coupling reactions (e.g., Suzuki, Stille) and for constructing complex heterocyclic compounds.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Research & Development: A valuable tool for academic and industrial R&D exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	1,1,1-Trifluoro-Methanesulfonic Acid 2-Acetylphenyl Ester
CAS No.	129849-05-4
Molecular Formula	C9H7F3O4S
Molecular Weight	268.21 g/mol
Synonyms	2-Acetylphenyl Trifluoromethanesulfonate; 1-(2-Hydroxyphenyl)ethanone Triflate; 2-Acetylphenyl Triflate; o-Acetylphenyl Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid 2-Acetylphenyl Ester; 2-Acetyl Phenyl Triflate; 2-Acetoxyphenyl Trifluoromethanesulfonate (incorrect but common alias); TFMS 2-Acetylphenyl Ester
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-Methanesulfonic Acid 2-Acetylphenyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.