Description

7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9,10-Difluoro-2,3-Dihydro-2-Methyl-7-Oxo-, (S)- (9Ci) is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key chiral building block in the synthesis of modern fluoroquinolone antibiotics, valued for its precise stereochemistry and structural complexity. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers for the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Critical chiral synthon for the synthesis of advanced fluoroquinolone antibiotics.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production chain for novel antibacterial drugs.
• Research & Development: Serves as a key starting material in medicinal chemistry for developing new antibacterial compounds with improved efficacy.
• Process Chemistry: Employed in scale-up and optimization studies for commercial drug production.
• Reference Standard: Used as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9,10-Difluoro-2,3-Dihydro-2-Methyl-7-Oxo-, (S)- (9Ci)
CAS No.	129798-65-8
Molecular Formula	C14H10F2N2O4
Molecular Weight	308.24 g/mol
Synonyms	(S)-9,10-Difluoro-2,3-dihydro-2-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (S)-Ofloxacin Intermediate; (S)-(-)-Ofloxacin Carboxylic Acid; Levofloxacin Intermediate; (S)-DR-3355; (S)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; (S)-(-)-Ofloxacine Carboxylic Acid
EINECS	Contact for details

Quality Control

Our 7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9,10-Difluoro-2,3-Dihydro-2-Methyl-7-Oxo-, (S)- (9Ci) is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (S-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.