Description

(2E)-4-(4-Methylpiperazin-1-Yl)-4-Oxobut-2-Enoic Acid is a high-purity pharmaceutical intermediate and building block with the CAS number 129795-76-2. This compound is valued for its role as a key synthon in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought by pharmaceutical manufacturers, contract research organizations (CROs), and fine chemical suppliers engaged in the production of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• API Synthesis: Used in the research and commercial-scale production of Active Pharmaceutical Ingredients (APIs) requiring a functionalized butenoic acid moiety.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Bioconjugation & Probe Development: The reactive alkene and carboxylic acid groups make it suitable for developing biochemical probes and conjugation linkers.
• Fine Chemical Manufacturing: Employed in the synthesis of specialized fine chemicals and advanced materials requiring specific piperazine derivatives.

Basic Information

Product Name	(2E)-4-(4-Methylpiperazin-1-Yl)-4-Oxobut-2-Enoic Acid
CAS No.	129795-76-2
Molecular Formula	C9H14N2O3
Molecular Weight	198.22 g/mol
Synonyms	(E)-4-(4-Methylpiperazin-1-yl)-4-oxobut-2-enoic acid; 4-(4-Methyl-1-piperazinyl)-4-oxo-2-butenoic acid; trans-4-(4-Methylpiperazin-1-yl)-4-oxobut-2-enoic acid; 2-Butenoic acid, 4-(4-methyl-1-piperazinyl)-4-oxo-, (2E)-; 129795-76-2; 4-(4-Methylpiperazine-1-carbonyl)but-2-enoic acid
EINECS	Contact for details

Quality Control

Our (2E)-4-(4-Methylpiperazin-1-Yl)-4-Oxobut-2-Enoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.