Description

Dehydro Aripiprazole is a key pharmaceutical intermediate and impurity reference standard used in the synthesis and quality control of the active pharmaceutical ingredient (API) Aripiprazole. This compound is critical for ensuring the purity, safety, and efficacy of final drug products targeting central nervous system disorders. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical manufacturers involved in the development and production of antipsychotic medications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthetic pathway for the production of Aripiprazole API.
• Analytical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of related substances in Aripiprazole drug substances and products via HPLC, LC-MS, or GC-MS.
• Impurity Profiling: Essential for method development and validation in stability studies to monitor degradation products and ensure drug quality and shelf-life.
• Process Chemistry Research: Employed in route scouting and optimization studies to improve the yield and purity of Aripiprazole synthesis.
• Regulatory Compliance: Supports regulatory filings (e.g., with FDA, EMA) by providing necessary impurity data for drug master files (DMFs) and investigational new drug (IND) applications.
• Quality Control (QC) Testing: Serves as an in-house control standard for pharmaceutical QC laboratories to verify assay results and impurity limits.

Basic Information

Product Name	Dehydro Aripiprazole
CAS No.	129722-25-4
Molecular Formula	C23H26Cl2N4O2
Molecular Weight	461.39 g/mol
Synonyms	7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one; Dehydro Aripiprazole; Aripiprazole Impurity; Aripiprazole Related Compound; UNII-6VW5Y1S2Q1; 1-(2,3-Dichlorophenyl)-4-[4-(2-oxo-3,4-dihydro-1H-quinolin-7-yloxy)butyl]piperazine; Aripiprazole Dehydro Impurity
EINECS	Contact for details

Quality Control

Our Dehydro Aripiprazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); prolonged exposure to air or moisture should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.