Description

o-Methyl Atovaquone is a key pharmaceutical intermediate and a methylated derivative of the antiprotozoal drug Atovaquone. This compound is of significant value in the research and development of novel therapeutic agents targeting parasitic infections. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced antiparasitic compounds and related analogs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Atovaquone and its structural analogs for antiparasitic medications.
• Antimalarial Research: Used in preclinical studies and drug discovery programs focused on developing new treatments for malaria and other protozoal diseases.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization for the scalable manufacturing of complex active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies investigating the mechanism of action of hydroxynaphthoquinone derivatives on mitochondrial electron transport.

Basic Information

Product Name	o-Methyl Atovaquone
CAS No.	129700-41-0
Molecular Formula	C23H22ClO3
Molecular Weight	381.87 g/mol
Synonyms	2-(4-Chlorophenyl)-3-(1,1-dimethylethyl)-6-methoxy-1,4-naphthalenedione; 2-(p-Chlorophenyl)-3-(tert-butyl)-6-methoxy-1,4-naphthoquinone; 6-Methoxy-2-(4-chlorophenyl)-3-(tert-butyl)-1,4-naphthoquinone; 3-tert-Butyl-2-(4-chlorophenyl)-6-methoxy-1,4-naphthoquinone; o-Methyl Atovaquone Impurity; Atovaquone Methyl Ether; Atovaquone Related Compound B
EINECS	Contact for details

Quality Control

Our o-Methyl Atovaquone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.