Description

Fmoc-(S,S)-[Pro-Leu]-Spirolactame is a specialized, high-purity synthetic intermediate featuring a unique spirocyclic lactam structure. This compound is critical for the synthesis of complex peptide-based molecules, offering enhanced conformational control and stability in advanced research applications. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutics, including protease inhibitors and constrained peptidomimetics.

Application

• Pharmaceutical Research & Development: A key building block for the synthesis of constrained peptide analogs and peptidomimetic drug candidates.
• Protease Inhibitor Design: Used to create structurally rigid scaffolds that mimic natural peptide substrates for enzyme inhibition studies.
• Chemical Biology: Employed in the development of molecular probes and tools to study protein-protein interactions and enzyme mechanisms.
• Peptide Library Synthesis: Serves as a unique, conformationally restricted amino acid derivative in combinatorial chemistry for drug discovery screening.
• Advanced Material Science: Potential precursor for designing bio-inspired polymers and materials with specific chiral and structural properties.

Basic Information

Product Name	Fmoc-(S,S)-[Pro-Leu]-Spirolactame
CAS No.	129605-53-4
Molecular Formula	C31H36N2O6
Molecular Weight	532.63 g/mol
Synonyms	Fmoc-(S,S)-Pro-Leu-Spirolactam; 9-Fluorenylmethyloxycarbonyl-(S,S)-prolyl-leucyl spirolactam; (3S,7aS)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(2S)-2-methylbutyl]hexahydro-1H-pyrrolo[1,2-c]imidazole-5,7-dione; Fmoc-Pro-Leu-SL; Fmoc-(S,S)-Pro-Leu-lactam; Spiro-lactam Fmoc-Pro-Leu derivative; N-α-Fmoc-(S,S)-[Pro-Leu]-lactam
EINECS	Contact for details

Quality Control

Our Fmoc-(S,S)-[Pro-Leu]-Spirolactame is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and structural confirmation via NMR and MS, to ensure it meets the stringent requirements for advanced pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.