Description

n-Boc-D-Leucine N'-Methoxy-N'-Methylamide CAS NO 129603-01-6 is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the controlled introduction of the D-leucine moiety into complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: As a key intermediate in solid-phase and solution-phase peptide synthesis (SPPS), particularly for incorporating D-configured leucine residues.
• Pharmaceutical Research: A vital precursor in the research and development of protease inhibitors, receptor agonists/antagonists, and other therapeutic peptides.
• Prodrug Development: Used to create protected intermediates for prodrug strategies, enhancing the stability and bioavailability of peptide-based drugs.
• Chemical Biology: Employed in the synthesis of labeled peptides and molecular probes for studying biological mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in the asymmetric synthesis of non-proteinogenic amino acids and complex natural products.

Basic Information

Product Name	n-Boc-D-Leucine N'-Methoxy-N'-Methylamide
CAS No.	129603-01-6
Molecular Formula	C₁₃H₂₆N₂O₄
Molecular Weight	274.36 g/mol
Synonyms	Boc-D-Leu-N(OMe)Me; (R)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanoic acid N-methoxy-N-methylamide; tert-Butyl (R)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate; D-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, N-methoxy-N-methylamide; Boc-D-Leu-NHOMe; N-(tert-Butoxycarbonyl)-D-leucine N'-methoxy-N'-methylamide; N-Boc-D-leucine Weinreb amide
EINECS	Contact for details

Quality Control

Our n-Boc-D-Leucine N'-Methoxy-N'-Methylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.