Description

4-(2,2,2-Trifluoroethoxy)Phenol is a high-purity fluorinated phenolic compound, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoroethoxy substituent, provides enhanced lipophilicity and metabolic stability, making it a valuable intermediate for the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production in pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine chemistry for improved product performance.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Building block for advanced herbicides, fungicides, and pesticides where the trifluoroethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Used in the synthesis of fluorinated components for high-performance liquid crystal displays (LCDs).
• Polymer Modification: Monomer or additive for creating specialty polymers with tailored surface properties and chemical resistance.
• Organic Electronics: Intermediate in the production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: Versatile reagent for exploring new fluorination strategies and structure-activity relationships in medicinal chemistry.

Basic Information

Product Name	4-(2,2,2-Trifluoroethoxy)Phenol
CAS No.	129560-99-2
Molecular Formula	C8H7F3O2
Molecular Weight	192.14 g/mol
Synonyms	4-Hydroxyphenyl 2,2,2-trifluoroethyl ether; 1-Hydroxy-4-(2,2,2-trifluoroethoxy)benzene; p-(2,2,2-Trifluoroethoxy)phenol; Phenol, 4-(2,2,2-trifluoroethoxy)-; 4-Trifluoroethoxyphenol; 2,2,2-Trifluoroethyl 4-hydroxyphenyl ether
EINECS	Contact for details

Quality Control

Our 4-(2,2,2-Trifluoroethoxy)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent quality suitable for sensitive synthesis applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.