Description

L-Proline, 1-Acetyl-4-Fluoro-, cis- (9Ci) is a high-purity, fluorinated proline derivative, a key chiral building block in advanced organic synthesis. Its value lies in its unique cis-configuration and fluorine substitution, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel peptide-based therapeutics and active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel peptide drugs and protease inhibitors.
• Agrochemical Synthesis: Used in the creation of advanced, fluorine-containing active ingredients with enhanced efficacy and environmental profile.
• Chemical Biology & Proteomics: Serves as a specialized probe or building block for studying enzyme mechanisms and protein-protein interactions.
• Peptidomimetics Development: Integral for designing and synthesizing stable peptide analogs with improved pharmacokinetic properties.
• Asymmetric Catalysis: Potential use as a ligand or catalyst component in stereoselective synthetic transformations.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting cutting-edge research in medicinal and synthetic chemistry.

Basic Information

Product Name	L-Proline, 1-Acetyl-4-Fluoro-, cis- (9Ci)
CAS No.	129512-85-2
Molecular Formula	C7H10FNO3
Molecular Weight	175.16 g/mol
Synonyms	(2S,4S)-1-Acetyl-4-fluoropyrrolidine-2-carboxylic acid; cis-4-Fluoro-L-proline, N-Acetyl-; N-Acetyl-cis-4-fluoro-L-proline; 1-Acetyl-cis-4-fluoro-L-proline; (4S)-1-Acetyl-4-fluoro-L-proline; Fluorinated L-Proline Derivative; N-Ac-4-F-L-Pro-OH; A building block for peptide synthesis
EINECS	Contact for details

Quality Control

Our L-Proline, 1-Acetyl-4-Fluoro-, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, assay, and purity is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.