Description

trans-1-Benzoyl-4-Hydroxy-L-Proline is a high-purity, non-natural proline derivative characterized by its specific stereochemistry and functional groups. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to introduce constrained proline analogs into peptide backbones to study structure-activity relationships and improve metabolic stability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce enantioselectivity.
• Bioconjugation & Probe Development: The benzoyl and hydroxy groups provide handles for further chemical modification in creating labeled compounds or molecular probes.
• Academic & R&D: Serves as a standard or starting material in medicinal chemistry and organic synthesis research within university and corporate laboratories.

Basic Information

Product Name	trans-1-Benzoyl-4-Hydroxy-L-Proline
CAS No.	129512-75-0
Molecular Formula	C₁₂H₁₃NO₄
Molecular Weight	235.24 g/mol
Synonyms	(2S,4R)-1-Benzoyl-4-hydroxypyrrolidine-2-carboxylic acid; (4R)-1-Benzoyl-4-hydroxy-L-proline; L-Proline, 1-benzoyl-4-hydroxy-, (4R)-; trans-4-Hydroxy-1-benzoyl-L-proline; 1-Benzoyl-4-hydroxy-L-proline, trans-; 4-Hydroxy-1-benzoyl-L-proline; Bz-Hyp-OH
EINECS	Contact for details

Quality Control

Our trans-1-Benzoyl-4-Hydroxy-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via IR and NMR. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.