Description

Methyl 4-Amino-5-Chloro-2-Hydroxybenzoate is a high-purity pharmaceutical intermediate with a distinct molecular structure that makes it a critical building block in modern synthetic chemistry. Its primary commercial value lies in its role as a precursor in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the gastrointestinal therapeutic area. This compound is essential for manufacturers in the pharmaceutical and fine chemical industries who require reliable, high-quality raw materials for producing advanced medications. Consistent purity and supply chain integrity are paramount for its successful application in regulated drug manufacturing processes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potent serotonin (5-HT4) receptor agonists and related prokinetic agents.
• API Synthesis: Core building block for the manufacture of gastroprokinetic drugs such as Mosapride, Cisapride, and related compounds.
• Fine Chemical Production: Used in research and development for creating novel benzamide derivatives with potential biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant drug production.
• Chemical Research: Serves as a standard or starting material in academic and industrial laboratories for methodological studies and new molecule discovery.

Basic Information

Product Name	Methyl 4-Amino-5-Chloro-2-Hydroxybenzoate
CAS No.	129511-06-4
Molecular Formula	C8H8ClNO3
Molecular Weight	201.61 g/mol
Synonyms	5-Chloro-4-amino-2-hydroxybenzoic acid methyl ester; Methyl 5-chloro-4-amino-2-hydroxybenzoate; 2-Hydroxy-4-amino-5-chlorobenzoic acid methyl ester; 4-Amino-5-chloro-2-hydroxybenzoic acid methyl ester; Benzoic acid, 4-amino-5-chloro-2-hydroxy-, methyl ester; CAS 129511-06-4; Mosapride intermediate
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-Amino-5-Chloro-2-Hydroxybenzoate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) are supplied with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, IR, and other pharmacopeial methods. Our quality commitment supports compliance with cGMP, ICH Q7 guidelines, and relevant customer-specific specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.