Description

tert-Butyl 5-(((Benzyloxy)Carbonyl)Amino)Indoline-1-Carboxylate is a high-purity, protected amino acid derivative and a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex molecules, particularly in the development of novel pharmaceuticals and bioactive compounds. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and biotechnology sectors who require reliable, high-quality raw materials for peptide synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key protected intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting neurological and oncological pathways.
• Peptide Synthesis: Serves as a specialized building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, where the tert-butyloxycarbonyl (Boc) and benzyloxycarbonyl (Cbz) protecting groups offer orthogonal deprotection strategies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce specific indoline-based scaffolds into novel drug candidates.
• Agrochemical Development: Employed as a synthetic precursor for creating new crop protection agents and herbicides with enhanced efficacy.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke organic compounds for client projects.

Basic Information

Product Name	tert-Butyl 5-(((Benzyloxy)Carbonyl)Amino)Indoline-1-Carboxylate
CAS No.	129487-93-0
Molecular Formula	C21H24N2O4
Molecular Weight	368.43 g/mol
Synonyms	1-Boc-5-[(benzyloxycarbonyl)amino]indoline; 5-[(Benzyloxycarbonyl)amino]indoline-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-5-[(benzyloxycarbonyl)amino]indoline; Boc-5-(Cbz-amino)indoline; tert-Butyl 5-(N-Cbz-amino)indoline-1-carboxylate; 5-Aminoindoline-1-carboxylic acid tert-butyl ester, N-Cbz derivative; N-Cbz-5-aminoindoline-1-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(((Benzyloxy)Carbonyl)Amino)Indoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged procedures to minimize degradation. Keep container tightly sealed in a dry environment to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.