Description

1-Boc-5-Amino-2,3-Dihydro-Indole is a high-purity, protected indole derivative serving as a critical building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and bioactive compounds. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile, protected amine and indole scaffold.
• Peptidomimetics & Heterocyclic Chemistry: Serves as a precursor for constructing complex heterocyclic systems and non-peptide bioactive molecules.
• Agrochemical Research: Employed in the development of new agrochemicals and plant growth regulators.
• Academic & Contract Research: A valuable reagent for academic research in organic synthesis and for CROs (Contract Research Organizations) supporting drug discovery programs.

Basic Information

Product Name	1-Boc-5-Amino-2,3-Dihydro-Indole
CAS No.	129487-92-9
Molecular Formula	C13H18N2O2
Molecular Weight	234.30 g/mol
Synonyms	5-Amino-2,3-dihydro-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate; 1-(tert-Butoxycarbonyl)-5-aminoindoline; 5-Amino-N-Boc-indoline; 1-Boc-5-aminoindoline; Boc-5-Aminoindoline; 129487-92-9
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Amino-2,3-Dihydro-Indole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We adhere to current Good Manufacturing Practices (cGMP) where applicable. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.