Description

(4S)-4-Benzyl-L-Glutamic Acid is a high-purity, non-proteinogenic amino acid derivative of significant importance in pharmaceutical research and development. Its chiral specificity and functionalized side chain make it a valuable chiral building block and intermediate for the synthesis of complex bioactive molecules. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in peptide synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected glutamic acid derivative in solid-phase and solution-phase peptide synthesis to introduce specific functional groups.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and metal complexes.
• Prodrug Design: Utilized in the design of prodrugs where the benzyl-protected glutamic acid moiety aids in targeted delivery or controlled release.
• Fine Chemical Synthesis: Acts as a versatile intermediate for the preparation of specialty chemicals and advanced materials.

Basic Information

Product Name	(4S)-4-Benzyl-L-Glutamic Acid
CAS No.	129446-71-5
Molecular Formula	C12H15NO4
Molecular Weight	237.25 g/mol
Synonyms	L-Glutamic acid, 4-(phenylmethyl)-, (4S)-; (S)-4-Benzylglutamic Acid; (S)-2-Amino-4-benzylpentanedioic Acid; 4-Benzyl-L-glutamic Acid; 4-Benzylglutamic Acid; (4S)-4-Benzylglutamic Acid; (S)-4-(Phenylmethyl)glutamic Acid; 4-(Phenylmethyl)-L-glutamic Acid
EINECS	Contact for details

Quality Control

Our (4S)-4-Benzyl-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.