Description

trans-4-Hydroxy-n-Triphenylmethyl-L-Proline Methyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide structures while preventing unwanted side reactions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce protected L-proline derivatives.
• Research & Development: Employed in academic and industrial labs for the development of novel peptidomimetics and constrained peptides.
• Bioconjugation: Acts as a linker or spacer molecule in the design of peptide-drug conjugates and other bioconjugates.
• Catalyst Ligand Preparation: Can be utilized in the synthesis of chiral ligands for asymmetric catalysis.
• Reference Standard: Serves as a high-purity analytical standard for quality control in peptide manufacturing.

Basic Information

Product Name	trans-4-Hydroxy-n-Triphenylmethyl-L-Proline Methyl Ester
CAS No.	129430-93-9
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	trans-4-Hydroxy-N-trityl-L-proline methyl ester; (2S,4R)-1-[(Triphenylmethyl)]-4-hydroxy-2-pyrrolidinecarboxylic acid methyl ester; Methyl (2S,4R)-4-hydroxy-1-trityl-2-pyrrolidinecarboxylate; N-Trityl-trans-4-hydroxy-L-proline methyl ester; Fmoc-Hyp(Tr)-OH methyl ester precursor; Protected trans-4-hydroxy-L-proline methyl ester; Hyp(Tr)-OMe; L-Proline, 4-hydroxy-1-(triphenylmethyl)-, methyl ester, (4R)-
EINECS	Contact for details

Quality Control

Our trans-4-Hydroxy-n-Triphenylmethyl-L-Proline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.