Description

Acetamide, n-(4-Methyl-2-Thiazolyl)-2-((1-Phenylethyl)Amino)-, Dihydro Chloride, (-)- is a high-purity, chiral organic compound of significant interest in advanced chemical synthesis. This molecule matters as a sophisticated building block, offering a defined stereocenter and a complex heterocyclic-acetamide structure for creating novel active ingredients. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of potential drug candidates and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-infective targets.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, or insecticides, leveraging its thiazole and acetamide functionalities.
• Chemical Biology Probe Development: Acts as a precursor for creating specialized molecular probes to study enzyme mechanisms or biological pathways.
• Asymmetric Catalysis Ligand Precursor: Its structure can be modified to develop novel chiral ligands for asymmetric synthesis applications.
• Academic & Institutional Research: Employed in university and contract research organization (CRO) labs for methodological studies in organic and medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Acetamide, n-(4-Methyl-2-Thiazolyl)-2-((1-Phenylethyl)Amino)-, Dihydro Chloride, (-)-
CAS No.	129340-81-4
Molecular Formula	C14H20N3OS • 2HCl
Molecular Weight	347.27 g/mol (Free base: 278.39 g/mol)
Synonyms	(-)-N-(4-Methyl-2-thiazolyl)-2-[(1-phenylethyl)amino]acetamide dihydrochloride; (S)-N-(4-Methylthiazol-2-yl)-2-((1-phenylethyl)amino)acetamide dihydrochloride; 2-[(1S)-1-Phenylethylamino]-N-(4-methyl-1,3-thiazol-2-yl)acetamide dihydrochloride; L-671,776 (as free base); A selective NK1 receptor antagonist intermediate; 2-((1-Phenylethyl)amino)-N-(4-methyl-2-thiazolyl)acetamide dihydrochloride, (-)-form
EINECS	Contact for details

Quality Control

Our Acetamide, n-(4-Methyl-2-Thiazolyl)-2-((1-Phenylethyl)Amino)-, Dihydro Chloride, (-)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.