Description

n-(4-Cyanophenyl)-L-Proline is a high-purity, non-natural amino acid derivative featuring a proline core with a 4-cyanophenyl substituent. This compound is a critical chiral building block and intermediate in modern pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other biologically active compounds.
• Peptidomimetics Research: Used to introduce conformational constraints and specific pharmacophores into peptide backbones during drug discovery.
• Asymmetric Synthesis: Serves as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Chemical Biology Probes: Employed in the development of molecular probes and tools for studying biological pathways and protein functions.
• Agrochemical Research: Potential intermediate in the development of advanced, targeted crop protection agents.
• Academic & Contract Research: Essential for fundamental organic chemistry research and custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	n-(4-Cyanophenyl)-L-Proline
CAS No.	129297-52-5
Molecular Formula	C₁₃H₁₂N₂O₂
Molecular Weight	228.25 g/mol
Synonyms	L-Proline, N-(4-cyanophenyl)-; (S)-1-(4-Cyanophenyl)pyrrolidine-2-carboxylic acid; 4-Cyano-N-L-prolylaniline; N-(4-Cyanophenyl)-(S)-proline; 129297-52-5; (2S)-1-(4-Cyanophenyl)pyrrolidine-2-carboxylic acid; N-(p-Cyanophenyl)-L-proline
EINECS	Contact for details

Quality Control

Our n-(4-Cyanophenyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral excess, and identification data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.