Description

Fmoc-o-tert-Butyl-L-Serine n-Carboxy Anhydride is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the efficient and racemization-free introduction of O-tert-butyl-L-serine into peptide chains, ensuring the integrity of complex biomolecules. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, sequential assembly of peptides, particularly in Fmoc-based strategies.
• Pharmaceutical Intermediate: Used in the research and development of peptide drugs, hormones, and vaccines that require serine residues with protected side chains.
• Bioconjugation & Labeling: Serves as a precursor for creating custom amino acids with reactive handles for attaching fluorophores, biotin, or other functional groups.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Institutional Research: Fundamental reagent for studying protein structure-function relationships, enzyme mechanisms, and signal transduction pathways.
• Production of Custom Peptides: Used by CROs and CDMOs for the reliable and scalable GMP or non-GMP manufacturing of therapeutic peptides.

Basic Information

Product Name	Fmoc-o-tert-Butyl-L-Serine n-Carboxy Anhydride
CAS No.	129288-44-4
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	Fmoc-Ser(OtBu)-OH NCA; Fmoc-O-tert-butyl-L-serine N-carboxyanhydride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-serine NCA; Fmoc-L-Ser(O-t-Bu)-NCA; Nα-Fmoc-O-tert-butyl-L-serine cyclic anhydride; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(2-methylpropan-2-yl)oxy]propanoic acid anhydride; Fmoc-Ser(tBu)-NCA
EINECS	Contact for details

Quality Control

Our Fmoc-o-tert-Butyl-L-Serine n-Carboxy Anhydride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR/IR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production protocols. Specifications can meet the requirements for standard laboratory use through GMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, maintain the recommended cold chain conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.